We’ve heard about the benefits of CBD and THC, but what about CBG?

We’ve heard about the benefits of CBD and THC, but what about CBG?

Posted by Madison Mayol on Jan 27th 2020

                              

Lately CBG has become an increasingly popular topic, yet the effects and benefits remain elusive. CBG stands for cannabigerol. It is one of the major cannabinoids found in young hemp plants. 

CBG is known as the pre-cursor to CBD and THC, which is why it is easily found in younger hemp plants. CBG can be compared to stem cells, which have the ability to develop into many different cell types and may work to repair damaged tissues. CBG has some ability to suppress the growth and development of bacteria. 

How does CBG work?

CBG works by binding to the CB2 receptors as a partial agonist. This means CBG produces less of an effect compared to a full agonist. This is one of the reasons why CBG has been overlooked as a cannabinoid. Yet our CB2 receptors exist all over our body; in our skin, spleen, bones, immune system, liver, bone marrow, and pancreas. 

Considering the antibacterial properties of CBG and its ability to bind to multiple receptors, we hope to achieve a better understanding of what this elusive cannabinoid can do for us. 

This blog will focus on CBG and its affinity for binding to our CB2 receptors, which are responsible for our immune system functioning optimally, and the possible correlation with its known antibacterial properties.

Why is CBG unique or useful?

Although it is a partial agonist, studies with mice have shown CBG to be particularly successful in reducing nitric oxide production and oxidative stress. Nitric oxide and oxidative stress are the underlying causes behind gastro intestinal issues and inflammatory bowel disease (IBD). 

According to the Department of Pharmacy in Naples, additional mice studies show that CBG successfully reduced murine colitis, which is intestinal inflammation caused by the presence of a chemical toxin in drinking water. According to the study, CBG reduced the overall size of the intestine as well as the formation of ROS (pollutants in the body) in intestinal epithelial cells. As such, it is now being considered for clinical experimentation with IBD patients.

CBG’s antibacterial properties can also help fight against a range of pathogenic bacteria. These antibacterial properties can be applied in medications, food containers, cosmetics, implants, and medical devices. It may even increase the functionality of wound dressings - considering its porous physical structure, air permeability, and absorbency capabilities. Lastly, it is lightweight, corrosion resistant, and inexpensive.

Overall, CBG exerts antioxidant effects in the inflamed gut as well as intestinal epithelial cells exposed to oxidative stress. Intensive research is needed to identify all the therapeutic uses for CBG. These studies could provide a pharmacological basis to explain the benefits of cannabis. The potential to create medical grade devices or implants using hemp could not only reduce the cost for patients, but also decrease the chances of infection or implant rejection.